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Radicicol, Humicola fuscoatra

C₁₈H₁₇ClO₆
M.W. 364.78
Assay: >98% by TLC & HPLC
Melting Point: 190℃-194℃
Solubility: Radicicol is Soluble in DMSO
Appearance: Yellow Powder

Radicicol is an antifungal antibiotic which acts as a Hsp90-specific inhibitor. 

RAPA, Rapamune, Sirolimus, AY-22989, NSC-226080, Rapamycin, Streptomyces hygroscopicus

C₅₁H₇₉NO₁₃
M.W. 914.2
Assay: >98%
Solubility: Rapamycin is soluble in DMSO and Methanol

Rapamycin is a triene macrolide antibiotic, which demonstrates anti-fungal, anti-inflammatory, anti-tumor and immunosuppressive properties. Rapamycin has been shown to block T-cell activation and proliferation, as well as, the activation of p70 S6 kinase and exhibits strong binding to FK-506 binding proteins. Rapamycin also inhibits the activity of the protein, mTOR, (mammalian target of rapamycin) which functions in a signaling pathway to promote tumor growth. Rapamycin binds to a receptor protein (FKBP12) and the rapamycin/FKB12 complex then binds to mTOR and prevents interaction of mTOR with target proteins in this signaling pathway. Rapamycin name is derived from the native word for Easter Island, Rapi Nui.

Merck Index., 1996., 12:, 8288., 2. Vezina, C., et al.. 
Purification and Characterization., J. Antibiot., 1975., 28:, 721., 3. Attur, M.G., R. Patel.,. 
Differential anti-inflammatory effects of immunosuppressive drugs: cyclosporin, rapamycin and FK-506 on inducible nitric oxide synthase, nitric oxide, cyclooxygenase-2 and PGE2 production., Inflamm Res., 2000., 49(1):, 20-26.. 

Store at -20℃

Handling: Hygroscopic. Protect from Light and Moisture.

Ristomycin, Spontin, Riston, Nocardia lurida

Assay: >90% Ristocetin A.
C₉₅H₁₁₀N₈O₄₄ for Ristocetin A

Ristocetin A is a glycopeptide antibiotic used in the diagnosis of the blood disorder, von Willebrand's disease. Ristocetin A is also antibacterial.

Ristocetin is Soluble in Aqueous solutions at an Acidic pH. 
Handling: Store in Tightly Sealed Vial. Protect from Moisture.
Merck Index, 1996., 12:, 8398., 2. Phillips, J.E., et al.. 
Antibiot. Ann. 1956-57, p.699., 3. Gottlieb, D., P. Shaw.,eds., Springer-Verlag, New York, 1967. pp 84-89., 1967., pp 84-89.. 

Store at 4℃

Handling: Store in Tightly Sealed Vial. Protect from Moisture.

Selection Antibiotics

C₄₃H₅₈N₄O₁₂·2H₂O
M.W.: 822.94
Assay: 99%min.
Heavy Matels: <20ppm
pH: 4.0~6.5

Rifampicin is active against gram-positive bacteria but less active against gram-negative bacteria. It interferes with the synthesis of nucleic acids by inhibiting DNA dependent RNA polymerase. Resistance to rifampicin can develop rapidly. The degree of resistance varies depending on the site of mutation in the RNA polymerase.

Stock conc.: 30 mg/ml in DMSO, MeOH
Working conc.: 150 µg/ml 

Store at 4℃

Harmful

DNA/RNA Experiment

Ribonuclease A
Pancreatic Activity: >60U/mg
Purity: 99%min.
DNase: None detected
origin from bovine pancreas, salt-free, freeze dried

Ribonuclease A (RNase A) is an endoribonuclease, that specifically cleaves single-stranded RNA 3' to pyrimidine residues (cytosine, uracil). Thereby, it generates pyrimidine-3'-phosphate or oligonucleotides with terminal pyrimidine-3'-phosphates.

Working conc.:10 μg/ml (removal of RNA from plasmid preparations; 1 hr, RT) or 100 ng/ml (preparation of "blunt ends" of double-stranded cDNA).

Ausubel, F.A., Brent, R., Kingston, R.E., Moore, D.D., Seidman, J.G., Smith, J.A. & Struhl, K. (eds.) (1995) Current Protocols in Molecular Biology. Greene Publishing & Wiley-Interscience, New York
Sambrook, J., Fritsch, E.F. & Maniatis, T.Molecular Cloning: A Laboratory Manual, 3rd Edition. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.

Store at -20℃